人参皂苷C-K对体内外银屑病模型的作用研究（英文）
发布时间：2022-12-21 22:31
本研究考察了人参皂苷C-K（C-K）在体内外银屑病模型中的作用。在体外,检测了C-K在人永生化表皮细胞（HaCaT细胞）中的作用,以及在鸡胚绒毛尿囊膜（CAM）中对血管生成的作用。在体内采用4种银屑病模型,包括:己烯雌酚处理的小鼠阴道上皮细胞模型、鼠尾颗粒细胞层形成模型、普萘洛尔诱导的豚鼠耳皮肤以及咪喹莫特诱导的BALB/c小鼠背部皮肤中的银屑病样特征模型。结果显示,C-K在体外可降低HaCaT细胞活力,抑制CAM血管生成。在体内,C-K改善了小鼠和豚鼠银屑病模型中的银屑病样组织学特征。C-K还可显著抑制小鼠阴道上皮细胞的有丝分裂,促进小鼠尾部鳞状上皮颗粒层的形成,降低普萘洛尔处理的豚鼠耳背侧角质层厚度;抑制了咪喹莫特诱导的BALB/c小鼠背部皮肤银屑病中皮肤增厚、水肿和炎性细胞浸润以及炎性因子的表达。据此可得出结论,C-K可以有效抑制银屑病动物模型,在临床研究中其对银屑病的治疗作用将得到进一步的探索应用。
【文章页数】：11 页
【文章目录】：
1 Drugs and Materials
1.1 Drugs and reagents
1.2 Experimental animals
1.3 Data analysis and statistics
2 Methods and Results
2.1 Efects ofC-Kon the pro liferatin and differentiation of keratinocytes in vitro
2.2 Effect of C-K on angiogenesis
2.3 Effect of C-K on mitosis of mouse vaginal epithelial cells
2.4 Effect of C-K on mouse tail scale epidermal granular layer formation
2.5 Effect of C-K on propranolol induced psoriasis in guinea pig ear skin
2.6 Effect of C-K on the model of imiquimod-induced BALB/c mouse psoriasis
2.7 The expression of inflammatory factors in the dorsal skin of imiquimod-induced BALB/c mice detected by ELISA
3 Discussion
4 Conclusion
本文编号：3722897
【文章页数】：11 页
【文章目录】：
1 Drugs and Materials
1.1 Drugs and reagents
1.2 Experimental animals
1.3 Data analysis and statistics
2 Methods and Results
2.1 Efects ofC-Kon the pro liferatin and differentiation of keratinocytes in vitro
2.2 Effect of C-K on angiogenesis
2.3 Effect of C-K on mitosis of mouse vaginal epithelial cells
2.4 Effect of C-K on mouse tail scale epidermal granular layer formation
2.5 Effect of C-K on propranolol induced psoriasis in guinea pig ear skin
2.6 Effect of C-K on the model of imiquimod-induced BALB/c mouse psoriasis
2.7 The expression of inflammatory factors in the dorsal skin of imiquimod-induced BALB/c mice detected by ELISA
3 Discussion
4 Conclusion
本文编号：3722897
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