肾上腺皮质腺瘤合并髓脂肪瘤的临床病理分析

发布时间：2018-10-24 13:14

【摘要】：目的肾上腺皮质腺瘤合并髓脂肪瘤国内外鲜有报道。文中探讨该肿瘤的临床病理特征,为正确诊断和治疗提供更多依据。方法回顾性分析2005年6月1日至2016年6月30日间南京总医院与南京江宁医院11例诊断为肾上腺皮质腺瘤合并髓脂肪瘤患者的组织学及临床资料,并结合结果与相关文献进行比较。结果 11例肾上腺皮质腺瘤合并髓脂肪瘤患者中,男4例、女7例,平均年龄(49.0±9.5)岁。其中3例患者出现Cushing’s综合征,1例反复发作头昏伴高血压十余年,其余7例均为体检偶然发现。影像学检查发现肾上腺占位。光镜下见髓脂肪瘤呈孤立性结节状分布和/或混杂分布于皮质腺瘤中,髓脂肪瘤由成熟脂肪组织和不同比例的造血细胞构成。11例患者均行肿物手术切除,术后随访2个月~11年均无肿块复发。结论肾上腺皮质腺瘤合并髓脂肪瘤临床少见,女性多见,患者可出现Cushing’s综合征、高血压或无明显临床症状,手术切除预后良好。
[Abstract]:Objective there are few reports of adrenal cortical adenoma complicated with myelolipoma at home and abroad. The clinicopathological features of the tumor are discussed in order to provide more evidences for correct diagnosis and treatment. Methods the histological and clinical data of 11 cases of adrenocortical adenoma with myelolipoma diagnosed in Nanjing General Hospital and Jiangning Hospital from June 1, 2005 to June 30, 2016 were retrospectively analyzed. The results were compared with the related literature. Results among 11 patients with adrenal cortical adenoma and myelolipoma, there were 4 males and 7 females with an average age of (49.0 卤9.5) years. Cushing's syndrome was found in 3 cases, dizziness in 1 case with hypertension for more than 10 years, and physical examination in 7 cases. Imaging findings revealed adrenal mass. Under light microscope, myelolipoma appeared as solitary nodular distribution and / or mixed distribution in cortical adenoma. Myelolipoma was composed of mature adipose tissue and different proportion of hematopoietic cells. There was no recurrence of tumor after 2 months to 11 years follow-up. Conclusion adrenal cortical adenoma complicated with myelolipoma is rare in clinic, and is more common in women. Cushing's syndrome may occur in the patients with hypertension or no obvious clinical symptoms, and the prognosis of surgical resection is good.
【作者单位】：南京军区南京总医院病理科;南京市江宁医院;南京医科大学病理学系;
【分类号】：R736.6

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