Treg/Th17比率与肥胖和2型糖尿病肾病的关系
发布时间：2024-01-20 17:47
背景2010年全球约有2.85亿人患有糖尿病,预计到2030年糖尿病患病人数将增加至4.39亿,相当于全球7.7%的20-49岁成年人的数量,大约90%的糖尿病为2型糖尿病。2型糖尿病的高血糖状态会导致血管、神经及器官的损伤。尽管中度的血糖升高不会使机体出现任何症状,但长期的高血糖会损伤机体,导致糖尿病并发症,如心脑血管疾病、神经损伤、糖尿病视网膜病变、糖尿病肾病等。如果肾脏小血管堵塞,空隙增大,肾脏的生理功能就会出现损害。传统观点认为,代谢和血液因素是引起糖尿病肾病的主要因素,新的研究显示,炎症在糖尿病肾病的进展中发挥重要作用,T细胞可能参与糖尿病肾病的发生和发展。CD4+辅助T细胞(Th)在调节免疫反应中发挥重要作用,最近有研究显示,除了Th1/Th2失衡以外,Th17/Treg失衡在一些自身免疫病、炎症性疾病和代谢性疾病如2型糖尿病中发挥重要作用。肥胖是已知的导致2型糖尿病进展的主要危险因素之一,而且肥胖与低度炎症相关。目的探讨2型糖尿病病人肥胖和是否存在Th17/Treg失衡及其与促炎因子和抗炎因子的相关性。研究设计本研究招募110名2型糖尿病病人,以尿白蛋白/肌酐比率(UCA...
【文章页数】：81 页
【学位级别】：博士
【文章目录】：
中文摘要 Abstract Abbreviations And Acronyms Introduction 1. Th17 And Treg Cells In Study Participants
1.1 Material
1.1.1 Reagent And Kits
1.1.2 Chemicals
1.1.3 Equipment
1.2 Methods
1.2.1 Study Subjects And Materials
1.2.2 Specimen
1.2.3 Cell Preparation Analysis
1.2.4 Surface Staining Protocol
1.2.5 Intracellular Staining Protocol
1.2.6 Ethical Consideration
1.2.7 Statistical Analysis
1.3 Results
1.3.1 Baseline Characteristics
1.3.2 Metabolic Panel Characteristics
1.3.3 Th17 Cells
1.3.4 Treg Cells
1.3.5 Th17/Treg Cells Ratio
1.4 Discussion
1.5 Summary 2. Serum Cytokines In Type 2 Diabetic Patients
2.1 Material
2.1.1 Reagent And Kits
2.1.2 Chemicals
2.1.3 Equipment
2.2 Methods
2.2.1 Study Subjects And Materials
2.2.2 Specimen
2.2.3 Cytokine Measurement
2.2.4 Ethical Consideration
2.2.5 Statistical Analysis
2.3 Result
2.3.1 Serum Cytokines
2.3.2 Il -6 In Study Participants
2.3.3 Il-10 In Study Participants
2.3.4 Il-21 In Study Participants
2.3.5 Il-23 In Study Participants
2.3.6 Tgf-Β1 In Study Participants
2.4 Discussion
2.5 Summary Conclusion Innovative Study Limitations References Publication And Project Review The Roles of Th17 and Treg Cells in Inflammatory Diseases
Introduction
1. Treg Cells
2. Differentiation Of Treg Cells
2.1 Natural Treg Cells
2.2 Inducible Treg Cells
3. Tregs And Involved Cytokines
4. Th17 Cells
5. Th17 Cells And Cytokines
6. Th17/Treg Balance And Diseases
7. Conclusion
Review References Acknowledgements 个人简历
本文编号：3881278
【文章页数】：81 页
【学位级别】：博士
【文章目录】：
中文摘要 Abstract Abbreviations And Acronyms Introduction 1. Th17 And Treg Cells In Study Participants
1.1 Material
1.1.1 Reagent And Kits
1.1.2 Chemicals
1.1.3 Equipment
1.2 Methods
1.2.1 Study Subjects And Materials
1.2.2 Specimen
1.2.3 Cell Preparation Analysis
1.2.4 Surface Staining Protocol
1.2.5 Intracellular Staining Protocol
1.2.6 Ethical Consideration
1.2.7 Statistical Analysis
1.3 Results
1.3.1 Baseline Characteristics
1.3.2 Metabolic Panel Characteristics
1.3.3 Th17 Cells
1.3.4 Treg Cells
1.3.5 Th17/Treg Cells Ratio
1.4 Discussion
1.5 Summary 2. Serum Cytokines In Type 2 Diabetic Patients
2.1 Material
2.1.1 Reagent And Kits
2.1.2 Chemicals
2.1.3 Equipment
2.2 Methods
2.2.1 Study Subjects And Materials
2.2.2 Specimen
2.2.3 Cytokine Measurement
2.2.4 Ethical Consideration
2.2.5 Statistical Analysis
2.3 Result
2.3.1 Serum Cytokines
2.3.2 Il -6 In Study Participants
2.3.3 Il-10 In Study Participants
2.3.4 Il-21 In Study Participants
2.3.5 Il-23 In Study Participants
2.3.6 Tgf-Β1 In Study Participants
2.4 Discussion
2.5 Summary Conclusion Innovative Study Limitations References Publication And Project Review The Roles of Th17 and Treg Cells in Inflammatory Diseases
Introduction
1. Treg Cells
2. Differentiation Of Treg Cells
2.1 Natural Treg Cells
2.2 Inducible Treg Cells
3. Tregs And Involved Cytokines
4. Th17 Cells
5. Th17 Cells And Cytokines
6. Th17/Treg Balance And Diseases
7. Conclusion
Review References Acknowledgements 个人简历
本文编号：3881278
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