细胞内蛋白质降解：通过溶酶体和泛素——蛋白酶体系统探索人类疾病和药物靶向治疗的未来（英文）

发布时间：2024-06-13 21:34

　　在真核细胞内主要存在两种蛋白降解系统,自噬—溶酶体系统和泛素—蛋白酶体系统(UPS),对维持蛋白稳态至关重要。本文综述了自噬—溶酶体系统和UPS的组成、功能、相互作用、功能相关性以及与肿瘤的关系,其作为药物靶标的可行性,对于未来肿瘤靶向药物的研制具有重要的指导作用,同时对于全面理解自噬—溶酶体系统和UPS的功能和机制也有重要的参考价值。

【文章页数】：17 页

【文章目录】：
1 Introduction
2 Introduction to eukaryotic protein deg-radation system
3 Ubiquitin as the core of UPS and au-tophagy
4 Ubiquitin-based proteasome
5 Ubiquitin-based autophagy degradation
6 Antagonism and interaction between 6UPS and autophagy
    6.1 Interference from UPS to autophagy
    6.2 Interference from autophagy to UPS
    6.3 Interplay between autophagy and UPS
    6.4 UPS and autophagy interaction
    6.5 Interaction between autophagy and UPS through the domain
7 Autophagy and cancer
8 UPS and cancer
9 DUB and cancer
1 0 DUB and autophagy simultaneous positioning
1 1 Human diseases and drug targeted therapy
1 2 Conclusions and prospects



本文编号：3993672