疼痛恐惧的认知神经基础
发布时间：2021-11-15 09:42
慢性疼痛（chronic pain,CP）通常是指在伤病愈合后仍持续并超过三个月的疼痛。其发生率较高,给患者个人及其家庭造成重大的身心和经济负担,并对社会健康系统产生消极影响。研究者已经对慢性疼痛的发生和维持机制进行了广泛关注。其中,恐惧回避模型（fear-avoidance model）强调了疼痛恐惧（fear of pain,FOP）在慢性疼痛的发生和维持过程中起着重要作用。疼痛恐惧是指对疼痛进行负面解释,即把疼痛等同于伤害,认为疼痛是灾难性的,导致在预期疼痛或体验疼痛时产生过度紧张、恐惧的情绪反应。疼痛恐惧可以通过直接经验、言语威胁信息和观察学习等途径获得,并且可以泛化到与原始恐惧相关的刺激或情境类似的新的刺激或情境中。目前已经有许多研究,采用行为指标（例如反应时和眼球运动）,在健康和临床样本中证明了较高的恐惧-回避相关信念和面对伤害性刺激时较差的功能反应存在很高的相关。但是,对疼痛恐惧潜在的认知神经基础的研究还相对较少,结果也存在不一致。此外,从动机的角度来看冲突情境中或者延迟情境下高疼痛恐惧个体的回避行为,可能会对恐惧回避模型有进一步的认识。研究1和研究2通过测量健康个体暴露...
【文章来源】：西南大学重庆市 211工程院校 教育部直属院校
【文章页数】：188 页
【学位级别】：博士
【文章目录】：
摘要
ABSTRACT
1 LITERATURE REVIEW
1.1 PAIN AND CHRONIC PAIN
1.2 FEAR OF PAIN
1.3 THE THEORY RELATED TO FOP
1.4 FORMULATION OF HYPOTHESIS
1.5 IMPORTANCE AND INNOVATIONS
2 STUDY1 FEAR OF PAIN AND EVENT-RELATED POTENTIALS DURING EXPOSURE TO IMAGE-CUED SENSORY STIMULATION
2.1 INTRODUCTION
2.2 MATERIAL AND METHODS
2.3 RESULTS
2.4 DISCUSSION
2.5 CONCLUSIONS
3 STUDY2 EFFECTS OF TRAIT FEAR OF PAIN ON EVENT-RELATED POTENTIALS TO WORD CUES THAT SIGNAL POTENTIAL PAIN
3.1 INTRODUCTION
3.2 MATERIAL AND METHODS
3.3 RESULTS
3.4 DISCUSSION
3.5 CONCLUSIONS
4 STUDY3 EFFECTS OF TRAIT FEAR OF PAIN ON NEURAL RESPONSES TO CUED POTENTIAL PAIN IN CHRONIC PAIN:AN FMRI STUDY
4.1 INTRODUCTION
4.2 METHOD AND MATERIALS
4.3 RESULTS
4.4 DISCUSSION
4.5 CONCLUSION
5 STUDY4 ASSOCIATIONS OF GRAY MATTER VOLUME TO THE PRESENCE OF CHRONIC PAIN:A PRELIMINARY VOXEL-BASED MORPHOMETRY STUDY
5.1 INTRODUCTION
5.2 MATERIAL AND METHODS
5.3 RESULTS
5.4 DISCUSSION
5.5 CONCLUSION
6 STUDY5 ALTERATIONS OF AMYGDALA RESTING-STATE FUNCTIONAL CONNECTIVITY IN YOUNG ADULTS WITH CHRONIC PAIN
6.1 INTRODUCTION
6.2 MATERIAL AND METHODS
6.3 RESULTS
6.4 DISCUSSION
6.5 CONCLUSIONS
7 STUDY6 TRAIT FEAR OF PAIN AS AN IMPACT ON DECISION MAKING IN CONFLICT SITUATIONS
7.1 INTRODUCTION
7.2 MATERIAL AND METHODS
7.3 RESULTS
7.4 DISCUSSION
7.5 CONCLUSIONS
8 STUDY7 THE IMPACT OF DENTAL PAIN FEAR ON TEMPORAL PREFERENCE:DISCOUNTING OF DELAYED PAIN-RELATED AND MONETARY OUTCOMES
8.1 INTRODUCTION
8.2 MATERIALS AND METHODS
8.3 RESULTS
8.4 DISCUSSION
8.5 CONCLUSION
9 GENERAL DISCUSSION
10 CONCLUSIONS
REFERENCES
APPENDIX
ACKNOWLEDGEMENTS
ARTICLES PUBLISHED
本文编号：3496531
【文章来源】：西南大学重庆市 211工程院校 教育部直属院校
【文章页数】：188 页
【学位级别】：博士
【文章目录】：
摘要
ABSTRACT
1 LITERATURE REVIEW
1.1 PAIN AND CHRONIC PAIN
1.2 FEAR OF PAIN
1.3 THE THEORY RELATED TO FOP
1.4 FORMULATION OF HYPOTHESIS
1.5 IMPORTANCE AND INNOVATIONS
2 STUDY1 FEAR OF PAIN AND EVENT-RELATED POTENTIALS DURING EXPOSURE TO IMAGE-CUED SENSORY STIMULATION
2.1 INTRODUCTION
2.2 MATERIAL AND METHODS
2.3 RESULTS
2.4 DISCUSSION
2.5 CONCLUSIONS
3 STUDY2 EFFECTS OF TRAIT FEAR OF PAIN ON EVENT-RELATED POTENTIALS TO WORD CUES THAT SIGNAL POTENTIAL PAIN
3.1 INTRODUCTION
3.2 MATERIAL AND METHODS
3.3 RESULTS
3.4 DISCUSSION
3.5 CONCLUSIONS
4 STUDY3 EFFECTS OF TRAIT FEAR OF PAIN ON NEURAL RESPONSES TO CUED POTENTIAL PAIN IN CHRONIC PAIN:AN FMRI STUDY
4.1 INTRODUCTION
4.2 METHOD AND MATERIALS
4.3 RESULTS
4.4 DISCUSSION
4.5 CONCLUSION
5 STUDY4 ASSOCIATIONS OF GRAY MATTER VOLUME TO THE PRESENCE OF CHRONIC PAIN:A PRELIMINARY VOXEL-BASED MORPHOMETRY STUDY
5.1 INTRODUCTION
5.2 MATERIAL AND METHODS
5.3 RESULTS
5.4 DISCUSSION
5.5 CONCLUSION
6 STUDY5 ALTERATIONS OF AMYGDALA RESTING-STATE FUNCTIONAL CONNECTIVITY IN YOUNG ADULTS WITH CHRONIC PAIN
6.1 INTRODUCTION
6.2 MATERIAL AND METHODS
6.3 RESULTS
6.4 DISCUSSION
6.5 CONCLUSIONS
7 STUDY6 TRAIT FEAR OF PAIN AS AN IMPACT ON DECISION MAKING IN CONFLICT SITUATIONS
7.1 INTRODUCTION
7.2 MATERIAL AND METHODS
7.3 RESULTS
7.4 DISCUSSION
7.5 CONCLUSIONS
8 STUDY7 THE IMPACT OF DENTAL PAIN FEAR ON TEMPORAL PREFERENCE:DISCOUNTING OF DELAYED PAIN-RELATED AND MONETARY OUTCOMES
8.1 INTRODUCTION
8.2 MATERIALS AND METHODS
8.3 RESULTS
8.4 DISCUSSION
8.5 CONCLUSION
9 GENERAL DISCUSSION
10 CONCLUSIONS
REFERENCES
APPENDIX
ACKNOWLEDGEMENTS
ARTICLES PUBLISHED
本文编号：3496531
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